Microvessel density and vascular endothelial growth factor receptors in breast carcinoma under the influence of rapamycin and platelet factor 4.
Identifieur interne : 000003 ( Main/Exploration ); précédent : 000002; suivant : 000004Microvessel density and vascular endothelial growth factor receptors in breast carcinoma under the influence of rapamycin and platelet factor 4.
Auteurs : Muhammad Shahidan Muhammad Sakri [Malaisie] ; Wan Faiziah Wan Abdul Rahman [Malaisie] ; Tengku Ahmad Damitri Al-Astani Tengku Din [Malaisie] ; Fauziah Mohd Idris [Malaisie] ; Hasnan Jaafar [Malaisie]Source :
- Indian journal of pathology & microbiology [ 0974-5130 ]
Abstract
Background
Vascular endothelial growth factor receptors (VEGFRs) are major endothelial growth factor receptors that influence the growth of a tumor. Microvessel density.
(
MVD) is the quantification method of various aspects of tumor vasculature that indicates angiogenic activity. This study aims to analyze the correlation between MVD to the expression of VEGFRs on breast cancer tissue.
Materials and Method
A total of 60 N-methyl-N-nitrosourea (MNU)-induced breast carcinomas in rats were suppressed by using antiangiogenic drugs. The rats were then sacrificed, and the tumor was fixed in 10% formalin, paraffin embedded, and immunohistochemistry stained using VEGFRs and CD34.
Result
One-way ANOVA test showed a significant difference in all markers that have been used (P < 0.05) on MNU-breast tumor treated with rapamycin (M= 90.1664, SD= 7.4487), PF4 (M= 93.7946, SD= 7.1303) and rapamycin + PF4 (M= 93.6990, SD= 1.8432). We obtained a significant reduction of MVD count on breast carcinoma for rapamycin group (M= 25.6786, SD= 9.7075) and rapamycin + PF4 group (M= 30.5250, SD= 13.6928) while PF4 group (M=47.7985, SD=4.8892) showed slightly increase compared to control (M= 45.1875, SD= 4.4786). There was a moderately strong, positive correlation between angiogenic markers; Flt-1 (r= 0.544, n=60, P < 0.005) and Flt-4 (r= 0.555, n= 60, P < 0.005) while Flk-1 (r= 0.797, n= 60, P < 0.005) showed a strong, positive correlation with MVD.
Conclusion
MVD was strongly correlated to the VEGFRs expression on breast carcinoma.
DOI: 10.4103/IJPM.IJPM_496_19
PubMed: 32317516
Affiliations:
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last="Jaafar">Hasnan Jaafar</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan</wicri:regionArea><wicri:noRegion>Kelantan</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020 Apr-Jun</date><idno type="RBID">pubmed:32317516</idno><idno type="pmid">32317516</idno><idno type="doi">10.4103/IJPM.IJPM_496_19</idno><idno type="wicri:Area/Main/Corpus">000088</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000088</idno><idno type="wicri:Area/Main/Curation">000088</idno><idno type="wicri:explorRef" wicri:stream="Main" 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sortKey="Abdul Rahman, Wan Faiziah Wan" sort="Abdul Rahman, Wan Faiziah Wan" uniqKey="Abdul Rahman W" first="Wan Faiziah Wan" last="Abdul Rahman">Wan Faiziah Wan Abdul Rahman</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan</wicri:regionArea><wicri:noRegion>Kelantan</wicri:noRegion></affiliation></author><author><name sortKey="Tengku Din, Tengku Ahmad Damitri Al Astani" sort="Tengku Din, Tengku Ahmad Damitri Al Astani" uniqKey="Tengku Din T" first="Tengku Ahmad Damitri Al-Astani" last="Tengku Din">Tengku Ahmad Damitri Al-Astani Tengku Din</name><affiliation wicri:level="1"><nlm:affiliation>Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan</wicri:regionArea><wicri:noRegion>Kelantan</wicri:noRegion></affiliation></author><author><name sortKey="Idris, Fauziah Mohd" sort="Idris, Fauziah Mohd" uniqKey="Idris F" first="Fauziah Mohd" last="Idris">Fauziah Mohd Idris</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan</wicri:regionArea><wicri:noRegion>Kelantan</wicri:noRegion></affiliation></author><author><name sortKey="Jaafar, Hasnan" sort="Jaafar, Hasnan" uniqKey="Jaafar H" first="Hasnan" last="Jaafar">Hasnan Jaafar</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan</wicri:regionArea><wicri:noRegion>Kelantan</wicri:noRegion></affiliation></author></analytic><series><title level="j">Indian journal of pathology & microbiology</title><idno type="eISSN">0974-5130</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>Background</b></p><p>Vascular endothelial growth factor receptors (VEGFRs) are major endothelial growth factor receptors that influence the growth of a tumor. Microvessel density.</p></div><div type="abstract" xml:lang="en"><p><b>(</b></p><p>MVD) is the quantification method of various aspects of tumor vasculature that indicates angiogenic activity. This study aims to analyze the correlation between MVD to the expression of VEGFRs on breast cancer tissue.</p></div><div type="abstract" xml:lang="en"><p><b>Materials and Method</b></p><p>A total of 60 N-methyl-N-nitrosourea (MNU)-induced breast carcinomas in rats were suppressed by using antiangiogenic drugs. The rats were then sacrificed, and the tumor was fixed in 10% formalin, paraffin embedded, and immunohistochemistry stained using VEGFRs and CD34.</p></div><div type="abstract" xml:lang="en"><p><b>Result</b></p><p>One-way ANOVA test showed a significant difference in all markers that have been used (P < 0.05) on MNU-breast tumor treated with rapamycin (M= 90.1664, SD= 7.4487), PF4 (M= 93.7946, SD= 7.1303) and rapamycin + PF4 (M= 93.6990, SD= 1.8432). We obtained a significant reduction of MVD count on breast carcinoma for rapamycin group (M= 25.6786, SD= 9.7075) and rapamycin + PF4 group (M= 30.5250, SD= 13.6928) while PF4 group (M=47.7985, SD=4.8892) showed slightly increase compared to control (M= 45.1875, SD= 4.4786). There was a moderately strong, positive correlation between angiogenic markers; Flt-1 (r= 0.544, n=60, P < 0.005) and Flt-4 (r= 0.555, n= 60, P < 0.005) while Flk-1 (r= 0.797, n= 60, P < 0.005) showed a strong, positive correlation with MVD.</p></div><div type="abstract" xml:lang="en"><p><b>Conclusion</b></p><p>MVD was strongly correlated to the VEGFRs expression on breast carcinoma.</p></div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">32317516</PMID><DateRevised><Year>2020</Year><Month>04</Month><Day>22</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">0974-5130</ISSN><JournalIssue CitedMedium="Internet"><Volume>63</Volume><Issue>2</Issue><PubDate><MedlineDate>2020 Apr-Jun</MedlineDate></PubDate></JournalIssue><Title>Indian journal of pathology & microbiology</Title><ISOAbbreviation>Indian J Pathol Microbiol</ISOAbbreviation></Journal><ArticleTitle>Microvessel density and vascular endothelial growth factor receptors in breast carcinoma under the influence of rapamycin and platelet factor 4.</ArticleTitle><Pagination><MedlinePgn>205-209</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.4103/IJPM.IJPM_496_19</ELocationID><Abstract><AbstractText Label="Background" NlmCategory="UNASSIGNED">Vascular endothelial growth factor receptors (VEGFRs) are major endothelial growth factor receptors that influence the growth of a tumor. Microvessel density.</AbstractText><AbstractText Label="(" NlmCategory="UNASSIGNED">MVD) is the quantification method of various aspects of tumor vasculature that indicates angiogenic activity. This study aims to analyze the correlation between MVD to the expression of VEGFRs on breast cancer tissue.</AbstractText><AbstractText Label="Materials and Method" NlmCategory="UNASSIGNED">A total of 60 N-methyl-N-nitrosourea (MNU)-induced breast carcinomas in rats were suppressed by using antiangiogenic drugs. The rats were then sacrificed, and the tumor was fixed in 10% formalin, paraffin embedded, and immunohistochemistry stained using VEGFRs and CD34.</AbstractText><AbstractText Label="Result" NlmCategory="UNASSIGNED">One-way ANOVA test showed a significant difference in all markers that have been used (P < 0.05) on MNU-breast tumor treated with rapamycin (M= 90.1664, SD= 7.4487), PF4 (M= 93.7946, SD= 7.1303) and rapamycin + PF4 (M= 93.6990, SD= 1.8432). We obtained a significant reduction of MVD count on breast carcinoma for rapamycin group (M= 25.6786, SD= 9.7075) and rapamycin + PF4 group (M= 30.5250, SD= 13.6928) while PF4 group (M=47.7985, SD=4.8892) showed slightly increase compared to control (M= 45.1875, SD= 4.4786). There was a moderately strong, positive correlation between angiogenic markers; Flt-1 (r= 0.544, n=60, P < 0.005) and Flt-4 (r= 0.555, n= 60, P < 0.005) while Flk-1 (r= 0.797, n= 60, P < 0.005) showed a strong, positive correlation with MVD.</AbstractText><AbstractText Label="Conclusion" NlmCategory="UNASSIGNED">MVD was strongly correlated to the VEGFRs expression on breast carcinoma.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Muhammad Sakri</LastName><ForeName>Muhammad Shahidan</ForeName><Initials>MS</Initials><AffiliationInfo><Affiliation>Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Abdul Rahman</LastName><ForeName>Wan Faiziah Wan</ForeName><Initials>WFW</Initials><AffiliationInfo><Affiliation>Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tengku Din</LastName><ForeName>Tengku Ahmad Damitri Al-Astani</ForeName><Initials>TADA</Initials><AffiliationInfo><Affiliation>Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Idris</LastName><ForeName>Fauziah Mohd</ForeName><Initials>FM</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jaafar</LastName><ForeName>Hasnan</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>India</Country><MedlineTA>Indian J Pathol Microbiol</MedlineTA><NlmUniqueID>7605904</NlmUniqueID><ISSNLinking>0377-4929</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Breast</Keyword><Keyword MajorTopicYN="N">MNU-induced breast carcinoma</Keyword><Keyword MajorTopicYN="N">microvessel density</Keyword><Keyword MajorTopicYN="N">vascular endothelial growth factor receptors</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>4</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>4</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>4</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32317516</ArticleId><ArticleId IdType="pii">IndianJPatholMicrobiol_2020_63_2_205_282697</ArticleId><ArticleId IdType="doi">10.4103/IJPM.IJPM_496_19</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Malaisie</li></country></list><tree><country name="Malaisie"><noRegion><name sortKey="Muhammad Sakri, Muhammad Shahidan" sort="Muhammad Sakri, Muhammad Shahidan" uniqKey="Muhammad Sakri M" first="Muhammad Shahidan" last="Muhammad Sakri">Muhammad Shahidan Muhammad Sakri</name></noRegion><name sortKey="Abdul Rahman, Wan Faiziah Wan" sort="Abdul Rahman, Wan Faiziah Wan" uniqKey="Abdul Rahman W" first="Wan Faiziah Wan" last="Abdul Rahman">Wan Faiziah Wan Abdul Rahman</name><name sortKey="Idris, Fauziah Mohd" sort="Idris, Fauziah Mohd" uniqKey="Idris F" first="Fauziah Mohd" last="Idris">Fauziah Mohd Idris</name><name sortKey="Jaafar, Hasnan" sort="Jaafar, Hasnan" uniqKey="Jaafar H" first="Hasnan" last="Jaafar">Hasnan Jaafar</name><name sortKey="Tengku Din, Tengku Ahmad Damitri Al Astani" sort="Tengku Din, Tengku Ahmad Damitri Al Astani" uniqKey="Tengku Din T" first="Tengku Ahmad Damitri Al-Astani" last="Tengku Din">Tengku Ahmad Damitri Al-Astani Tengku Din</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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